| Author Name | Affiliation | | Yu Mao | State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China | | Yan Li | State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China | | Ning Gu | State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China |
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| Abstract: |
| With unique physical properties, chemical properties, and biological effects, magnetic nanomaterials are important functional materials in many fields. In the past decades, iron based magnetic nanomaterials have attracted much attention in the biomedicine field due to their superior magnetic properties and great potential in biomedical applications. In particular, magnetic iron oxide nanoparticles (MIONPs) have been playing a crucial role in the biomedicine field because of their diagnostic and therapeutic functions. Meanwhile, MIONPs are benign, low toxic, biocompatible, and biodegradable, so they are the only inorganic magnetic nanomaterials approved by the U.S. Food and Drug Administration (FDA) for clinical use at present. In this review, we mainly introduce the progress in the preparation of iron based magnetic nanomaterials for biomedical applications, including pure iron nanoparticles, iron-based alloy nanoparticles, and MIONPs, with a focus on MIONPs. Also, we summarize the preparation methods of MIONPs and point out the importance of their developments. |
| Key words: iron based magnetic nanomaterials biomedical applications MIONPs diagnostic and therapeutic functions preparation methods |
| DOI：10.11916/j.issn.1005-9113.2018004 |
| Clc Number:TB34 |
| Document Code::A |
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| Descriptions in Chinese: |
| 综述：生物医用铁基磁性纳米颗粒的制备研究进展 毛宇，李艳，顾宁 （东南大学 生物科学与医学工程学院，江苏省生物材料与器件重点实验室，生物电子学国家重点实验室，南京 210096） 摘要：磁性纳米材料具有独特的物理性能、化学性能以及生物效应，是一类重要的功能材料，可以应用于很多领域。在过去的几十年，铁基磁性纳米材料由于其优越的磁性能和巨大的生物医用潜力在生物医学领域引起了大量的关注。特别是具有诊断和治疗功能的磁性氧化铁纳米颗粒一直在生物医学领域发挥着重要作用。磁性氧化铁纳米颗粒是良性的、低毒的、生物相容且生物可降解的，是目前美国食品及药物管理局批准的唯一可用于临床的无机磁性纳米材料。本综述主要介绍了生物医用铁基纳米材料包括铁单质纳米颗粒、铁基合金纳米颗粒及磁性氧化铁纳米颗粒的制备研究进展，重点介绍了磁性氧化铁纳米颗粒的制备方法，并总结指出了磁性氧化铁纳米颗粒制备方法发展的重要性。 关键词: 铁基磁性纳米材料；生物医用；磁性氧化铁纳米颗粒；诊断和治疗功能；制备方法 |
