| Related citation: | Bo Chen,Peng Zhao,Qiwei Wang,Zhanhang Guo,Xin Liu,Yan Li,Yue Zhang,Min Ji,Ning Gu.γ-Fe2O3@carboxymethyl Cellulose as Potential Oral Nanomedicine for Iron Deficiency Anemia Treatment on Rats[J].Journal of Harbin Institute Of Technology(New Series),2020,27(3):158-169.DOI:10.11916/j.issn.1005-9113.20034. |
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| γ-Fe2O3@carboxymethyl Cellulose as Potential Oral Nanomedicine for Iron Deficiency Anemia Treatment on Rats |
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| Author Name | Affiliation | | Bo Chen | Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China
Materials Science and Devices Institute, Suzhou University of Science and Technology, Suzhou 215009, Jiangsu, China | | Peng Zhao | Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China | | Qiwei Wang | Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China | | Zhanhang Guo | Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China | | Xin Liu | Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China | | Yan Li | Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China | | Yue Zhang | Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China | | Min Ji | Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China | | Ning Gu | Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210096, China |
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| Abstract: |
| Oral iron supplements such as ferrous iron salts are major treatment agents for iron deficiency anemia (IDA) due to the convenience of large dose administration and good patient compliance. However, the gastrointestinal adverse impact caused by Fe2+ stimulus and low bioavailability severely impedes its therapeutic effects. In recent years, it has been found that nano iron-based nanoparticles with high surface-to-volume ratio and low iron ion leakage can alleviate the toxic effect and improve the gastrointestinal absorbance. For further clinical development, nano materials need to meet the pharmaceutical quality demand. Carboxymethyl cellulose (CMC) is a significant pharmaceutical ingredient applied in approved drug formulations, and polyglucosorbitol carboxymethylether (PSC) has been utilized in iron-based nanomedicine ferumoxytol synthesis, both of which can be firmly anchored on iron oxide by carboxyl chelation. In this work, iron oxide nanoparticles (NPs) modified with CMC were designed and synthesized, and the structure composition and physicochemical properties were distinctly characterized. Oral supplement effects on rat IDA were investigated and compared with other recently reported iron supplements including NPs modified with PSC. Results show that the oral nano iron supplement achieved the recovery of hemoglobin and serum iron level in only two weeks with high safety. The nano iron oxide modified with pharmaceutical excipients provides new potential approach for oral iron supplement available in clinics. |
| Key words: iron oxide nanomedicine carboxymethyl cellulose polyglucosorbitol carboxymethylether oral agent iron deficiency anemia |
| DOI：10.11916/j.issn.1005-9113.20034 |
| Clc Number:R318.08 |
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| Descriptions in Chinese: |
| 羧甲基纤维素修饰的伽马三氧化二铁纳米颗粒作为口服纳米药物用于大鼠缺铁性贫血的治疗 陈博1,2#，赵鹏1#，王琪炜1，郭占航1，刘鑫1，李艳1，张玥1，吉民1，顾宁1 * (1.东南大学 生物科学与医学工程学院，生物电子学国家重点实验室，江苏省生物材料与器件重点实验室，南京210096; 2.苏州科技大学 材料科学与器件研究院，江苏 苏州215009) #共同第一作者 中文说明：#$TAB口服补铁剂如二价铁盐是现今治疗缺铁性贫血的主要药物，该类药物的特点是能够大剂量应用且患者具有良好的顺应性。但是，二价铁盐的生物利用度较低，会通过Fe2+刺激对机体胃肠道产生副作用，这些缺点严重制约了其治疗效果。为了减轻口服铁剂的毒副作用同时改善铁元素的胃肠道吸收，具有高比表面积与低铁离子泄露率的铁基纳米颗粒被开发出来。而进一步的临床发展则需要纳米材料达到药品质量的严格标准。羧甲基纤维素（CMC）是一种已广泛应用于药物制剂的辅料，聚葡萄糖山梨醇羧甲基醚（PSC）则是铁基纳米药物ferumoxytol的包覆材料，这两种医药用材料均能够通过自身的羧基稳固的螯合在氧化铁颗粒的表面。因此，本工作设计并合成了表面修饰CMC的铁基纳米颗粒，对其结构组成与物化性质进行了明确的表征。研究了该颗粒对大鼠缺铁性贫血的口服治疗效果，并与其他一些补铁剂包括PSC包裹的氧化铁颗粒进行了对比。结果发现该口服纳米补铁剂能够在两周内有效恢复血红蛋白与血清铁的水平，且无明显的毒副反应发生。药用辅料修饰的氧化铁纳米颗粒为临床用口服纳米补铁剂的发展提供了一种新的研究思路与方法。 关键词：氧化铁纳米药物，羧甲基纤维素，聚葡萄糖山梨醇羧甲醚，口服药物，缺铁性贫血 |
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