To research the shear-compression behavior of mortar-less masonry which has potential in the reinforcement concrete frame and masonry structures, 36 shear-compression tests were carried under cyclic loads. During the test, the influence of cyclic shear-compress load on the behavior was emphasized. After that, a finite element model was built with interface and plain stress elements. The research indicates that the coulomb friction law is adequate to represent the failure of mortar-less joints under moderate stress levels, the friction coefficient varies under different load aptitude which can’t be ignored and the model with interface element and plane stress element is valid in simulation of shear-compression test.