Transport route optimization of dangerous goods makes lower transportation risk and cost of the enterprise, meanwhile it provides basis reference for the government decision. On the basis of urban master planning, the characteristics of transport of dangerous goods was analyzed, and then the index system on transport of dangerous goods was established. In order to implement this research and quantify the indicators, road characteristics and nature of land along the section has been used to evaluate the risk, simultaneously, the emergency response capacity was considered as the correction factor to improve the risk model, and the BPR impedance function was applied to calculate the transportation costs, then the calculation process of transportation risk and costs was given with an example of Pingxiang, Jiangxi. On this basis, a bi-objective optimization model was created with the target of risk and cost, and method of solving the model was discussed. This model provides a theoretical basis for the transport network of dangerous goods planning and design for its simplicity, practicality and operability.