According to the application of the 2^nd generation lifting reentry vehicle, a further research and analysis was performed for the TAEM. Based on the space shuttle's trajectory and guidance of TAEM, several parameters of TAEM trajectory are analyzed, and the ground trajectory and altitude profiles of TAEM are designed by optimization. Also, the longitudinal and lateral guidance laws are given in order to make simulation verification for the reference trajectory. Simulation results satisfy all of the trajectory constraints, and the guidance algorithm has been proved effective and accurate. The guidance method validates that the guidance is feasibility and validity for TAEM of the 2nd generation lifting reentry vehicle.