To ensure the safe design of coal mine refuge chamber, we investigate the strength and deformation of the chamber under explosion. Based on the principle of gas explosion, numerical simulation was performed using ANSYS/LS-DYNA software and ALE fluid-solid coupling algorithm on the flow filed of underground tunnel explosion caused specifically by 9.5％ concentration of 200 m³ gas. Systemically analyses were done on the relationship between the pressure field as well as plastic strain distributions and the dynamic response through the displacement-time curves. The cross-section dimension of the chamber surface where it faces to the explosion directly can significantly influence the anti-explosion performance. The camber with corrugated sidewall structure can imperatively enhance the bending rigidity of the bulkhead. However, there is no much influence on the anti-explosion properties of the carbine by changing its length.