Aiming at the problem of large number of the weathered granite existed along the expressway, and to recycle the excavation and meet the social and economic benefits, this paper attempts to improve the properties of weathered granite material which is easy to disintegrate and poorly graded. The lime-fly-ash-cement was used to improve the weathered granite material for the pavement sub-base. Three different mix proportion, the mass ratio of cement∶lime∶fly-ash∶weathered granite is:Ⅰ (2∶4∶16∶78),Ⅱ (2∶6∶14∶78),Ⅲ (2∶8∶12∶78) were tested; And four tests of compaction, strength, dry shrinkage and temperature shrinkage were taken to evaluate the effect of road base course performance of lime-fly-ash-cement stabilized weathered granite material. The tests result shows that the strength decreases first and then keeps stable with the increasing of lime, and keeps stable first and then increases with the increasing of fly-ash. The plan I and Ⅱ have bigger maximum dry density, the compressive strength and spilt strength of plan I are the biggest, those of plan II are the second. The drying shrinkage of plan I and II is similar, and that of plan III is the worst. The rule of temperature shrinkage is the same to the drying shrinkage rule. According to the experimental result, the best mix proportion scheme is mix proportion I (2∶4∶16∶78), which is suitable to the pavement sub-base.