To monitor the pressure distribution in urban water distribution system (WDS), a method of locating pressure monitoring points is proposed based on district model of WDS. First, Euclidean distance is introduced to measure the pressure fluctuation similarity between two nodes within a running cycle. Whether a node in a pipe is classified as one sub-district depends on that the Euclidean distance values between the node and other nodes of this sub-district is within a given maximum allowable Euclidean distance. Finally, a node with minimum average Euclidean distance in a sub-district is chosen as its pressure monitoring point location. This district method is applied to monitoring point layout of a practical WDS. The analysis results show that different district solutions are obtained by changing the maximum allowable Euclidean distance. All the nodes in each sub-district are connected and the Euclidean distance between any two nodes is within a given maximum allowable value. After placing one pressure monitoring point in each sub-district, the results show that the pressure distribution in WDS can be effectively reflected, when average relative error is 4.53％ and the number of pressure monitoring point is four.