To reduce the generation and development of reflection cracks of the semi-rigid base asphalt pavement, of which the fatigue performance using the HDPE-rubber powder to modify asphalt composite as a stress absorbing layer was studied. The fatigue test was carried out and the data after choosing proper test method and determining the mixture proportion and final experiment scheme was analyzed. Experimental results showed that asphalt modified by HDPE-rubber powder had excellent anti-fatigue ability and could effectively delay the generation of reflection cracksin asphalt pavement. This was verified by the observation results of indoor asphalt pavement test.