In order to carry out the near and far-field seismic vulnerability, the seismic vulnerability model of a certain typical irregular highway continuous rigid frame bridge of China was created. Considering the uncertainty of near and far-field earthquake and bridge parameters, by adopting sampling method, the model sample database was generated to carry out bridge seismic vulnerability analysis. In order to obtain the structural near and far-field dynamic response respectively, every model in the database was calculated by using nonlinear time history analysis by using the software such as OpenSees. And the pier and bearing damage index were obtained. Then based on the above studied results, and then the near and far-field fragility curves of bridge dangerous members were obtained by using the probabilistic seismic demand analysis method and then a comparative study analysis for near and far-field seismic vulnerability for the structural damage state was determined. The results showed that, the vulnerability condition of the bridge component was closely related to spectral characteristics of ground-motion and irregular structure, and the near-field damage probability was significantly higher than the far-field's; so it was very necessary to carry out vulnerability research according to near and far fault ground motion. Finally the fragility curves obtained can be used to evaluate the seismic performance of irregular bridges, and can provide the basis for post-earthquake damage assessment.