To accurately determine the vibration reduction effect of single-layer reticulated shells with friction pendulum bearings (FPB), based on the refined finite element models, the isolation mechanism of FPB was given, and single-layer reticulated shells with FPB were analyzed from two aspects of static and dynamic. Structures were analyzed in three aspects including the internal force, deformation and stability under static loading, and were also researched through dynamic time-history analysis under 3-D earthquake waves. The impact of ground motion intensities and parameters of FPB on the seismic performance of single-layer latticed shell was discussed. The analysis results indicate that the static mechanics performance of a single-layer reticulated shell with FPBs can be improved by strengthening the outer ring bars. Under 3-D earthquakes, the bigger the ground motion intensity, the better isolation performance of FPB will be. The optimal friction coefficient of FPB increased with the increase of ground motion intensity. The bigger friction pendulum bearing curvature radius is, the better seismic performance of reticulated shell structure will be.