In order to prevent the methane disaster in coal mine effectively and obtain the reasonable parameters of promoting methane extraction by coal seam water infusion, the 2103 working face of Changcun coal mine was investigated as an example. Using the coupling of VOF model of Fluent software and porous medium model, promoting methane drainage by coal seam water infusion and its influence factors was simulated based on the multi-phase porous flow theory. The comparison shows that the simulation results were basically consistent with the measured data. The results are detailed as follow. The gas content in coal seam gradually decreased with the increase of the radial distance from centerline of water injection hole and it increased with the increase of the radial distance from centerline of gas drainage hole. During drainage period before water injection, the scope of drainage increased gradually and gas flow in drainage hole decreased quickly at first, and then decreased slowly. During the stage of water injection, the scope of drainage increased and water injection flow decreased gradually, while gas flow in coal seam and gas flow in drainage hole also increased gradually over time. And after water injection, the coverage area of pressure water continued to increase, while gas content in coal seam and gas flow in drainage hole both declined little by little over time. The opportunity, time, pressure, layout, pressure, space between boreholes and the way of water injection are the 6 main factors which influence the effect of promoting methane extraction by coal seam water infusion. It can achieve the best effect when intermittent water injection was carried out for 10 days under the pressure of 8 MPa water injection according to the way of one injection and one pumping and arranging the drilling holes spacing at 5 m after 20 days of the methane drainage.