To realize the NO oxidation at low temperature, the NO catalytic oxidation efficiency through Fenton reagent/AC coupled with microwave in the liquid system and within 23~65 ℃ temperature range was researched, in which the AC acts as wave absorption heating-spots based on its developed pores. At first, the invigorating effect of microwave on Fenton reagent was proved using compared experiment in detail, including thermal effect and sensitization effect. Then the effect of the microwave power, the initial pH value, the AC dose, the Fe²⁺ initial concentration and the H₂O₂ initial concentration on the NO removal efficiency was studied thoroughly, the optimal reaction parameters were reached at last. The results indicated that the AC combined with microwave could enhance the NO removal efficiency substantially. The optimal reaction parameters was that the microwave power was 400 W, the pH value was 3, the AC dose was 4 g, the Fe²⁺ initial concentration was 5 mmol/L and the H₂O₂ initial concentration was 0.3 mol/L. The NO removal efficiency under the optimal reaction conditions was up to 46.3%.