To improve the stress and deformation of long span CFST arch bridge during concrete pouring, a self-regulating loading pouring method was proposed based on the stress and deformation influence line of arch rib. The theoretical formulas between weighted bending moment energy and concrete age of arch ring were deduced, and a method of optimizing perfusion interval was introduced to minimize the difference of weighted bending moment energy between staged and primary bridge constructions, which can avoid early bearing of filled concrete. A perfusion simulation program for New Longmen bridge was developed using the APDL of ANSYS, and the optimization analysis of segmental pouring for CFST arch bridge was performed. Results show that the proposed self-regulating loading pouring method could be applied to CFST arch bridge, and the self-control of deformation and stress during construction could be realized with the pouring scheme based on the stress and deformation influence line. The optimization method aiming at minimizing the difference of the weighted bending moment energy between staged and primary bridge constructions could reasonably determine the staged perfusion time for long span CFST arch bridge. Comparing with the methods such as temporary cable and water tank, the self-regulating loading pouring method could reduce auxiliary process and decrease the total cost of the construction.