Based on the advantages of concrete filled steel tube (CFST) column and reinforced concrete (RC) beam, a new type of CFST column-RC beam joint connected by U-shaped steel plate and studs is proposed in this paper. In order to study the seismic performance of the new type of joint, two full-scale CFST column-RC beam joints and one traditional RC joint were designed and manufactured, and the low-cycle reciprocating load test was carried out. Results show that the failure mode of the CFST column-RC beam joint was similar to that of the traditional RC joint that both of the joints had flexural failure at beam ends. The failure area was mainly outside the U-shaped steel plate edge, and the plastic hinge area moved outwards. The beams of the cross joint were named as S beam and N beam according to the specimen installation positions of the test site. Compared with the RC joint, the bearing capacity of the N beam of CFST column interior joint and side joint increased by 11.6% (13.0% in negative direction) and 5.3% (7.5% in negative direction) respectively, and that of the S beam of the CFST column interior joint increased by 20.2% (19.6% in negative direction). The load-displacement hysteresis curves showed a plump shape. The accumulative energy dissipation of the CFST column interior joint and side joint increased by 17.0% (36.0% for S beam) and 20.1% compared with the RC joint. The displacement ductility coefficient of each specimen was higher than 4.0, and that of the interior joint and side joint of the CFST column-RC beam increased by 2.4% and 21.3%. Therefore, the new type of CFST column-RC beam joint showed good deformation ability.