To improve the authenticity and reliability of the air combat decision-making and trajectory generation process, the air combat decision-making process should focus on the reliable aerodynamic coupling model and the operational performance of the guided weapon. Therefore, the unmanned combat aerial vehicle (UCAV) trial maneuvering decision based on missile attack state assessment was proposed. First, the construction idea of the UCAV trial maneuvering decision system was analyzed. Next, a UCAV heuristic maneuver decision scheme was established based on aerodynamic coupling model, and 1 331 UCAV trial maneuver strategies were designed by means of fine division. Then, based on the operational application of air-to-air missile, a decision evaluation function including angle, distance, and energy decision factors was constructed, and a maneuver decision method was designed according to the principle of statistics. Finally, a weight factor grading model based on missile attack state assessment was proposed and constructed to ensure the weight of the decision factor changed adaptively with missile attack state. By setting up UCAV and target respectively in two sets of confrontation conditions under three different initial combat situations, simulation experiments were conducted to verify the decision-making ability and effective level of the proposed trial maneuver decision-making scheme and weight factor grading model under different combat situations. This method provides an idea for solving the air combat decision-making problems combined with actual air-to-air missile combat applications, and the constructed decision-making strategy is conducive to giving full play to the operational performance of air-to-air missile.