To investigate the moving stability of trucks and cars under crosswind, a driving simulator study based on the eight degree-of-freedom motion system was carried out. The simulation platform was established for the bridge-tunnel section of expressway in mountain area under crosswind. Thirty participants were recruited, and six scenarios were designed with each run in a different crosswind condition. By comparing and analysing the lateral displacement, yaw rate, and lateral acceleration of cargo truck and car under crosswind, the sideslip stability, yaw stability, and roll stability of the vehicles were discussed. Based on the static stability factor, the concept of overturning ratio was proposed to compare the anti-overturning ability of different vehicles. Results show that the car was more prone to sideslip when driving in the bridge-tunnel section under crosswind, and the cargo truck had more serious side drift under continuous crosswind. The car, with a shorter crosswind perception time, could respond to the crosswind environment faster than the cargo truck. The risk of truck rollover was higher under crosswind, and there was still a certain risk of rollover after the cargo truck drove out of the crosswind area.