In order to improve the anti-cracking performance of tuff manufactured sand concrete, the mixing ratio of manufactured sand and stone powder content were taken as the main influencing factors, and the quantitative evaluation method of concrete cracking risk based on tubular cracking test was proposed. At the same time, the working performance, mechanical properties, impermeability and sulfate corrosion resistance of tuff manufactured sand concrete were systematically studied. The test results indicated that the workability and strength of all machine-made sand concrete were the best when the content of stone powder is 5%(mass fraction). The sulfate resistance and impermeability gradually were decreased with the increase of stone powder content, and the possibility of dry shrinkage and cracking were greater. For the concrete mixed with natural sand and manufactured sand, the mechanical properties of concrete decreased gradually with the increase of the proportion of natural sand; Under the proportion of 30% natural sand, it has good sulfate resistance and permeability resistance. Although the fully manufactured sand concrete is not as good as the natural sand concrete in terms of workability, it is superior in strength and crack resistance. Using manufactured sand to replace natural sand can get better benefits, but at the same time, the limit of stone powder content should be strictly controlled (the mass fraction not more than 7%). When natural sand and tuff machine-made sand are mixed, the comprehensive performance of concrete is the best under the mixing ratio of 30% natural sand.