Marshy-lacustrine clays with bonding characteristic, soil structure and initial anisotropy were formed by shrinkage of lake wetlands and ancient lake wetlands. In order to effectively describe the stress-strain relationship and yield characteristics of marshy-lacustrine clays, an elastic-plastic constitutive model of soil taking into account evolution of bonding strength, soil structure and initial anisotropy effects was established. A bonding strength evolution law used for three stress states including isotropic compression, shear and a combined action of compression and shear was proposed, based on the variation law of bonding strength under shear stress path and the corresponding relationship between yield surfaces and bonding strength with isotropic compression. On the basis of the Modified Cambridge model, the hardening law was improved by considering the evolution law of bonding strength and the influence of volumetric strain hardening and shear strain hardening. To reflect the effect of initial anisotropy, anisotropic parameters η_NCL was introduced and polar coordinate transformation was performed for the p′-q space. A structured and anisotropic constitutive model considering bonding for soil was presented by using the correlated flow rule. All parameters of the structured and anisotropic constitutive model considering bonding can be obtained through isotropic compression tests, triaxial test, and K₀ consolidation tests. The comparison between model predictions and experimental results shows that the proposed model can reasonably capture the influences of bonding strength, soil structure and initial anisotropy on the stress-strain and yield characteristics of marshy-lacustrine clays. The structured and anisotropic constitutive model considering bonding for marshy-lacustrine clays can effectively reflect the gradual degradation of bonding strength during loading and the improvement of bonding strength on soil tensile strength under unloading stress path. This model takes into account the influence of bonding strength, soil structure and anisotropy, which can reasonably characterize the mechanical response of marshy-lacustrine clays.