| 引用本文: | 孙瑜,宋莉,马万里,张子峰,王立,刘丽艳.石化工人多环芳烃暴露促进高血压中介机制分析[J].哈尔滨工业大学学报,2025,57(5):22.DOI:10.11918/202405003 |
| SUN Yu,SONG Li,MA Wanli,ZHANG Zifeng,WANG Li,LIU Liyan.Analysis of mediating mechanisms of polycyclic aromatic hydrocarbon exposure in hypertension among petrochemical workers[J].Journal of Harbin Institute of Technology,2025,57(5):22.DOI:10.11918/202405003 |
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| 石化工人多环芳烃暴露促进高血压中介机制分析 |
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孙瑜1,2,宋莉3,马万里1,2,张子峰1,2,王立1,刘丽艳1,2
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(1.哈尔滨工业大学 环境学院,哈尔滨 150090;2.城市水资源与水环境国家重点实验室(哈尔滨工业大学), 国际持久性有毒物质联合研究中心,哈尔滨 150090;3.黑龙江省劳动卫生职业病研究所/黑龙江省第二医院,哈尔滨 150028)
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| 摘要: |
| 为探究氧化应激和炎症在多环芳烃暴露和血压升高风险关系中的中介作用,筛选746名石化工人为对象,基于血压水平将其分为正常血压组和高血压组,同时测定尿液中10种羟基多环芳烃（OH-PAHs）和6种氧化应激生物标志物（OSBs）,结合外周血白细胞计数（WBC）,利用回归模型分析OH-PAHs、OSBs、WBC与血压之间的关联,并采用中介效应模型评估OSBs和WBC在OH-PAHs与血压关联中的作用。结果表明:高血压组尿液中2-羟基萘（2-OH-Nap）和2&3-羟基芴（2&3-OH-Flu）水平显著高于正常血压组（P<0.05）；OH-PAHs与6种OSBs均显著相关（P<0.001）；2-OH-Nap和2&3-OH-Flu质量分数每增加一个lg单位,外周血WBC分别升高17.0%（β=0.170,P=0.002）和23.3%（β=0.233,P<0.001）；尿液8-异前列腺素F2α（8-PGF2α）和外周血WBC质量分数每增加一个lg单位,高血压发生风险分别增加6.16倍（RO=6.16,P=0.031）和27.8倍（RO=27.8,P=0.018）；8-PGF2α和WBC在2-OH-Nap与舒张压的关系中起中介作用,中介比例分别为21.0%和37.0%,仅WBC在2&3-OH-Flu引起血压升高中起中介作用。石化工人多环芳烃暴露主要通过诱导炎症反应而增加患高血压风险。 |
| 关键词: 羟基多环芳烃 高血压 氧化应激 炎症 中介作用 |
| DOI：10.11918/202405003 |
| 分类号:R135 |
| 文献标识码:A |
| 基金项目:黑龙江省省属科研院所科研业务费项目(CZKYF2020C024,CZKYF2023-1-B043) |
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| Analysis of mediating mechanisms of polycyclic aromatic hydrocarbon exposure in hypertension among petrochemical workers |
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SUN Yu1,2,SONG Li3,MA Wanli1,2,ZHANG Zifeng1,2,WANG Li1,LIU Liyan1,2
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(1.School of Environment, Harbin Institute of Technology, Harbin 150090, China; 2.International Joint Research Center for Persistent Toxic Substances, State Key Laboratory of Urban Water Resources and Environment(Harbin Institute of Technology), Harbin 150090, China; 3.Heilongjiang Institute of Labor Hygiene and Occupational Diseases/The Second Hospital of Heilongjiang Province, Harbin 150028, China)
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| Abstract: |
| To investigate the mediating role of oxidative stress and inflammation in the relationship between polycyclic aromatic hydrocarbon exposure and increased blood pressure, a study was conducted involving 746 petrochemical workers. Participants were selected and divided into normal blood pressure group and hypertension group based on their blood pressure values. Ten mono-hydroxylated polycyclic aromatic hydrocarbons(OH-PAHs) and six oxidative stress biomarkers(OSBs) in urine were determined. White blood cell count(WBC) was derived from workers′ blood routine examination results. The associations between urinary OH-PAHs, urinary OSBs, peripheral WBC and blood pressure were analyzed by regression models, the roles of OSBs and WBC in the relationship between OH-PAHs and blood pressure were evaluated by mediating effect model. The results indicated that 2-hydroxynaphthalene(2-OH-Nap) and 2&3-hydroxyfluorene(2&3-OH-Flu) levels in hypertension group were significantly higher than those in normal blood pressure group(P<0.05). OH-PAHs were significantly correlated with 6 OSBs(P<0.001). For each unit increase in concentrations of 2-OH-Nap and 2&3-OH-Flu, the peripheral blood WBC increased by 17.0%(β=0.170, P=0.002) and 23.3%(β=0.233, P<0.001), respectively. Additionally, for each unit increase in urinary 8-iso-prostaglandin F2α(8-PGF2α) and peripheral WBC, the risk of developing hypertension increased by 6.16 times(RO=6.16, P=0.031) and 27.8 times(RO=27.8, P=0.018), respectively. The relationship between urinary 2-OH-Nap and diastolic blood pressure was partially mediated by 8-PGF2α and WBC, with a mediation ratio of 21.0% and 37.0%, respectively. Only WBC partially mediated the effect of 2&3-OH-Flu on blood pressure elevation. In conclusion, polycyclic aromatic hydrocarbon exposure among petrochemical workers primarily increases the risk of hypertension through the induction of inflammatory responses. |
| Key words: mono-hydroxyl PAHs hypertension oxidative stress inflammation mediation effect |
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