To investigate out-of-plane behavior of infilled frame due to different construction measures,collapse simulation of the structure is carried out by LS-DYNA software.The influences of construction measures of infilled frame and grades of mortar are researched,respectively.The results show that the collapse prevention capacity of infill walls is effectively improved by increasing the grade of mortar and setting steel tie bars.The space of tie bars is advice to reduce when infilled structures are beyond the eighth seismic precautionary intensity.Other reasonable measures can be also adopted to protect infill walls from collapse and ensure the safety of people’s life and possessions.