To set up inherent immune response of the adjustable fuzzy matching negative selection immune algorithm,based on fuzzy idea,the vaccine theory is used to pick up the vaccine during abnormal monitoring,and the algorithm performance influenced by vaccine operator and positive selection operator is studied.The simulation results show that the antibody storeroom memory function is increased by the vaccine operator and the second response period is shorten obviously,while the positive selection operator is the executant.The improved adjustable fuzzy matching negative selection algorithm has better self-study function,it has self-adaptation for the inherent immune response.