In this paper,a maneuvering penetration optimization for trajectory of lift reentry vehicle is researched.At first,a model for this problem is proposed and its trajectory optimization theory is studied,and then the multi-constraints and multi-phases trajectory optimization is unified in an optimization algorithm.The direct method and sequential quadratic programming algorithm are used to solve the trajectory optimization problem,and finally the maneuvering penetration optimization trajectory which satisfies corresponding constraint is obtained.The simulation results show that the model proposed in this paper is reasonable and feasible with good results.