To study the variation of cutting temperature in high-speed milling of titanium alloy with polycrystalline diamond,factorials design and uniform design were applied to the cutting temperature experiments.The main effects and interaction effect which have significant influence on cutting temperature were found out by factorials design.By using uniform design,the influence law of main effects and interaction effects on cutting temperature were investigated.Nonlinear mathematical model on the relationship between cutting parameters and cutting temperature was established.The results show that under high speed milling,the interaction effect between cutting speed and width of the uncut chip is significant.The relationship between cutting temperature and cutting parameters is nonlinear,and the effect of one cutting speed on cutting temperature changes with width of the uncut chip.