To reduce the vertical seismic response of vertical storage tanks with fluid-structure coupling motion,according to the boundary conditions and potential theory,the hydrodynamic was given by selecting reasonable velocity potential. Considering hydrodynamic and soil-structure interaction,the control equation of vertical isolation storage tanks was established and the theoretical expression of wall shear, bending moment and stress were given. Seismic response analysis was carried out with Wilson-θ method selecting 150 000 m³ storage tanks. The results showed that: a vertical base isolation system storage tank could reduce the seismic response of radius, axial and hoop stress. It is necessary to take various factors into account to select the best site, isolation period, damping ratio and height-radius ratio in design of different storage tanks.