To know the function of protective measures for reticulated shell subjected to internal blast loading, a fine finite element model for Kiewitt8 single-layer reticulated shell which contained reticulated shell member, purlin hanger, purlin, rivet, roof boarding, wall and ground was established by using finite element software ANSYS/LS-DYNA. The effect of reinforcement for reticulated shell member, selection of roof boarding and openings in the wall was studied by using ALE (Arbitrary-Lagrange-Euler) algorithm. The results showed that by selecting the outer-loop members to reinforce, choosing light roof boarding or thin roof boarding, increasing the opening rates and the height of position, and reducing the opening spacing, the dynamic response of the reticulated shell under internal blast loading could be reduced effectively.