An integrated approach of potassium permanganate composites and polymeric ferric sulfate was used to strongthen the effect on the removal of simulated thallium and antimony combined pollution in surface water. Jar tests and micro-travelling experimentation platform tests were used to optimize the operation conditions, then the main factor for removing thallium (Tl) and antimony (Sb) combined pollutants was discussed. The results show that the initial water containing 0.21-0.35 μg·L-1 (2-3 times) thallium(Tl) and 15-20 μg·L-1 (3-4 times) antimony (Sb) can be treated to satisfy the Chinese drinking water quality standard, simultaneously the corresponding operation condition are as follows: the pH value of raw water should be adjust to 5.7-6.3, the dose of PPC was higher than 3 mg·L-1 and a dosage of PFS was higher than 40 mg·L-1. And furthermore, the dosage of potassium permanganate composites(PPC) was the key factor for thallium(Tl) removal,while the dosage of polymeric ferric sulfate(PFS) and pH of raw water were the key factors for antimony(Sb) removal.