The thermal response psychology experiments were conducted for college students wearing winter clothes in three experimental conditions, overall slightly cool, overall neutral asymmetrical cold radiation and overall neutral uniform. The environmental and physiological parameters were recorded. Meanwhile, the subjects were asked to fill in the questionnaires on five local and overall thermal sensation and thermal comfort. The results show that, in the slightly cool and neutral asymmetrical cold radiation conditions, the head and back thermal sensation have no significant difference; while the hand, arm, lower leg and overall thermal sensation are different. In the neutral non-uniform condition, overall thermal sensation votes were lower than those in the uniform condition, although the mean indoor temperature of the former condition was higher. The temperature difference between head and foot increased for the subjects near the exterior window and wall because of cold radiation, which led to the people felt cold at their legs and the overall thermal sensation and comfort decreased. In the slightly cool and neutral conditions with cold radiation, overall thermal sensation followed the thermal sensation for cooler parts, and overall thermal comfort followed the most uncomfortable parts, following the “complaint” modes. In the uniform condition and asymmetrical cold radiation environments, overall thermal sensation votes and thermal comfort votes have good linear correlation. The air temperature for the lower body such as lower legs should be increased, which led to leg local thermal sensation improved, and overall thermal sensation and thermal comfort would be improved.