To study the effects of COF on wear of high pair, a wear prediction model of cylinder-on-flat configuration was established with the finite element method (FEM) and the commercial FE software ANSYS. The wear volume is computed by a modified Archard equation, and the material loss caused by wear is simulated by moving contact boundary nodes in FEM model. The simulation results, which have been verified by experiments, show that the lower COF would generate the larger contact pressure and slip that produces more wear volume. The larger COF would accelerate the generation of fatigue.