To obtain the optimal process parameters, the orthogonal test and response surface methodology coupled with central composite design were applied in the optimization of electro-Fenton process as advanced treatment of coal chemical industry wastewater, and a quadratic model was developed to predict the treatment performance. The results showed that the factors affecting TOC removal in descending order was pH, current density and Fe2+ concentration according to the orthogonal test. The developed quadratic model could predict the response accurately, and the optimal parameters were determined as pH 4.3,1.56 mmol／L of Fe2+ and 14.74 mA／cm² of current density, with the predicted optimal TOC removal efficiency of 61.58％. The electro-Fenton could serve as a effective technology for the advanced treatment of coal chemical industry wastewater.