To obtain the seismic performance of single-layer reticulated domes with friction pendulum bearings (FPB), finite element refined models of FPB were applied to 80 m K8 single-layer reticulated domes FE Model. The same earthquake waves were exerted to single-layer reticulated shells with hinge support or FPB. The isolation effect of FPBs was analyzed in two main aspects including the dynamic responses of bars and nodes of reticulated domes, and the impact of FPB parameters on the seismic response of single layer latticed shell were discussed. The results indicate that the optimal friction coefficient of FPB increases with the increase of the ground motion intensity. The bigger curvature radius of FPB, the smaller seismic responses of reticulated shell structure will be. On the basis of the above research, this paper gave some discussion how friction pendulum bearings were selected for single-layer reticulated domes.