In order to explore frost heaving properties of gravel soil containing mud in seasonal frozen region of Qinghai-Tibet Plateau, and provide the foundation for airport engineering anti-freezing expansion design, Particle analysis experiment and compaction experiment were conducted to provide the basis indoor frost heaving rate experiment. Then it improved for gravel soil particle size characteristics of large heaving rate based on traditional means of laboratory experiments, following the improved apparatus a series of sets of orthogonal frost heave indoor tests were conducted to study the influence of factors including degree of compaction, moisture content, silt content, overlying load, water replenishing on frost heaving ratio by the improved experiment device. The test results show that frost heaving ratio of gravel soil containing mud in seasonal frozen region of Qinghai-Tibet Plateau showed a trend of decrease after the first increase with the increase of degree of compaction in a sealed environment, and approaches its maximum at the compaction degree of 95%; increases linearly with the increase of moisture content, increases with the increase of silt content corresponding to a polynomial function; Gently decreases at an exponential functional with the increase of overlying load. Frost heaving ratio increases over three times under the condition of the water replenishing. Multi-factor regression forecast formula is obtained by the multiple regression analysis. The influence of various factors on frost heaving ratio decreasing order:water replenishing, moisture content, silt content, degree of compaction, overlying load. Consequently, it is the key of anti-freezing expansion design to control water replenishing, moisture content, silt content.