To determine the proper values of process parameters when milling the pre-sintering zirconia denture, the optimization calculation is made to increase the material removal rate and decrease the surface roughness by using the ideal point method, minimum deviation method and linear combination method in finish milling process. Taking molar crown upper surface milling as a project for finding the suitable tool path planning method, the path planning is made by UG CAM. The cavity milling following periphery planning method is used for the rough machining. The reciprocating mode of surface milling, following periphery mode of area milling and reciprocating mode of area milling is used for the finish machining. It is found that the better surface quality can be acquired by the method of reciprocating mode of area milling for finish machining according to the results and contrast of the experiment in the same optimization values of the process parameters and standard tools.