To prevent reinforced concrete (RC) frame columns from seismic shear failure caused by additional shear force of the infill wall, severe shear failures of RC frame columns investigated in recent earthquakes were presented. Finite element modeling (FEM) pushover analysis with ABAQUS and mechanical characteristics analysis on 6 infilled RC frames were conducted. Then a RC frame structure subjected to LuDian Ms6.5 earthquake was analyzed by ABAQUS. The analysis indicates that the additional shear force of the infill wall results in the shear failure of the column. To ensure that a structure operates in a high-ductility mode, an estimation formula was developed for the additional shear force which could be used in structure design. The case study shows that without appropriate considerations about the additional shear force of the infill wall, anti-collapse capability of the structure will be threatened seriously. Analysis also demonstrates that the additional shear force estimation formula is in well accordance with the FEM analysis result and the seismic damage investigations, it can be a reference for engineering design.