To understand the rate-dependent mechanical properties and failure mechanism, a series of uniaxial off-axial tensile tests were carried out to study the mechanical properties of three common PTFE (Poly tetra fluoro ethylene) coated fabrics under different tensile rates. The following parameters were considered in the tests including eleven in-plane directions (0°, 5°, 15°, 25°, 35°, 45°, 55°, 65°, 75°, 85°and 90°) and six tensile rates (10 mm/min, 25 mm/min, 50 mm/min, 100 mm/min, 200 mm/min, and 500 mm/min). The variations of main mechanical parameters of PTFE coated fabrics were analyzed and the corresponding tensile failure modes and mechanisms were studied. The results show that the variations of main mechanical parameters are consistent under different tensile rates and it shows significant anisotropic characteristic. The tensile strength is strongly related with the failure modes. With tensile rate increasing, the tensile strength increases slightly while the strain at break decreases. The tensile strength shows good linear relationship with the tensile rate's logarithm, which is mainly related with the strain energy and the woven structure. The change of tensile rate has no significant effects on the material failure modes and the strain at break.