To quickly identify whether seismic high-locality landslides could threaten the line project at high-intensity mountains, potential disaster prediction of seismic high-locality landslide is proposed. According to hydrogeology condition, slope units are divided by GIS technology. Discriminant model of seismic high-locality slopes threatening line project is established. The model contains energy and path conditions. Both of two conditions are met, it can be ensured that seismic high-locality slope threatening the line project after losing stabilities. Zoning map of the seismic high-locality slopes threatening line project in study area can be obtained. Case analysis results indicate that this model approach can identify quickly which seismic high-locality landslides could threaten the line project under complex slope conditions, and provide a decision basis for location design and reconstruction of existing lines project at high-intensity mountains, and can also be used to guide designers to complete sketchy space alignment and multi-objective decision quickly in mountain.