This paper addresses the scientific problems in bearing accelerated life test, such as lack of multi-stress acceleration model, and not well understanding of failure law. Firstly, the interface micro failure mode and mechanism of fluid lubricated bearing under environment of vacuum, temperature, preload, speed and microgravity are analyzed. Secondly, the micro contact uniform lubrication model considering multi-stress comprehensive working mechanism is derivated and established, and the numerical solution method based on improved Newton Raphson method is proposed. Thirdly, the orthogonal simulation scheme with 5 factors and 5 levels orthogonal table is designed, the bearing failure law in the work of vacuum, temperature, preload, speed and microgravity is simulated and analyzed, and the failure response value of micro contact surface film thickness, pressure peak, friction factor, maximum undersurface stress which changes with the stress level and contact region dimension is obtained. Finally, the multi-stress acceleration model about vacuum, temperature, preload, speed and microgravity based on response surface method has been established, which is verified by a test of actual engineering example.