Located in the east of China, Tancheng-Lujiang fault zone is a region with frequent seismic events. Earthquakes above 4.0 occur multiple times there, most of which concentrate in its middle and northern segments. Yi-Shu fault zone is located in the middle of Tancheng-Lujiang fault zone, where earthquakes above 6.0 have occurred. To study the influence of sites on the ground motion of the Yi-Shu fault zone and explore groud motion estimating method for regions lack of seismic data, the ground motion wave form of Yi-Shu fault zone is analyzed by Fourier spectrum, and the high frequency reduction effect of sites in Shandong on Yi-Shu fault zone ground motion is studied. The high frequency reduction parameter Kappa is obtained, whose relationship with the site average shear wave velocity V_S30 is subsequently discussed. Kappa’s influence on seismic parameters such as PGA and response spectrum S_a is also investigated. Results show that as a parameter characterizing site conditions, Kappa exhibits regional differences, which decrease with the increase of corresponding V_S30. Under the same earthquake magnitude, Kappa only affects the numerical value of PGA and response spectrum, while their respective decay trends remained unaffected. The high frequency reduction parameter Kappa attains in this study can provide reference for research on the site effect in Shandong for earthquakes of Yi-Shu fault zone, as well as the simulation of the Yi-Shu fault zone ground motion and the analysis of its characteristics.