Prestressed concrete (PC) pipe pile has poor seismic performance compared with ordinary concrete piles. To improve the performance, a new type of mesh-constrained PC pipe pile is proposed. Through the quasi-static test of four PC pipe pile specimens, which are divided into two groups under different axial compression ratios, effects of reinforcement form and axial compression ratio on their seismic performance were investigated. One group had a new type of meshed constraint and the other had common spiral constraint. The axial compression ratios of each group were 0.3 and 0.5 respectively. The failure process was recorded in detail, and the hysteresis curve, skeleton curve, load-bearing capacity, deformation ability, stiffness degradation curve and energy consumption capacity of the test specimens were obtained. Results show that all test specimens were subjected to flexural failure, and the ductility factor was between 2.99 and 3.96. The meshed constrained test specimens had large energy consumption, and its hysteresis loop was fuller than the spiral constrained specimens. The load-bearing capacity, ductility and energy dissipation capacity of the specimens were greatly affected by the axial compression ratio. The larger the axial compression ratio, the greater the load-bearing capacity and the worse the ductility and energy dissipation capacity. A formula of flexural capacity of the PC pipe piles with meshed constrain stirrups is proposed and the formula of the PC pipe piles subjected to the high axial compressive ratio is modified.