Due to the adverse effects of traffic noise on human hearing, blood pressure, and cardiovascular system, reducing traffic noise interference and realizing indoor natural ventilation have become the key technical problems of street-facing buildings. To effectively solve this problem, a new sound insulation ventilation device was designed, and a corresponoling sound insulation ventilation model as well as a calculation model of fresh air volume was established. According to the simplified model of sound insulation ventilation, a Simulink simulation model was constructed. Effects of ambient noise and frequency on the sound insulation performance of the device were analyzed through experiments. The ventilation experimental data were compared with the simulation results to verify the accuracy of the Simulink simulation model. Influence of ventilation volume and ventilation chamber volume on the ventilation effect of the device was studied by Simulink simulation model. Then an optimization scheme was put forward, and the ventilation effect of the optimized device was simulated. Experiment results show that the indoor noise of running device was approximately the same as that when the window was closed. The sound insulation effect of the device was more ideal for medium and high frequency ambient noise. The Simulink simulation model could reflect the ventilation effect well. When the ventilation chamber volume was matched with the economic ventilation volume, the economic efficiency was the best. By adopting the further optimized device, the fresh air volume of single bedroom could reach 35.16 m³/h and the CO₂ volume fraction could be controlled within 1 030×10^-6, which meets the requirements of indoor air quality.