To study the differences of various ground motion parameters in the selection of horizontal bidirectional ground motion records, by taking the “Code for Seismic Design of Buildings” (GB 50011—2010) as an example, the differences of ground motion characteristics and structural responses of selected records were compared. The records were selected in order of error by linear amplitude and full period spectrum matching method under two working conditions, which were then input to 4-story and 12-story concrete frame structures to analyze the story displacement angle and story shear force. Meanwhile, the characteristics and sensitivity of the selected ground motion records were compared. Results show that the structural response, scaling coefficient, and ground motion characteristics of the records selected by the maximum direction spectrum have less discreteness in comparison with those of sum of mean square spectrum and geometric average spectrum. Compared with the target spectrum, the records selected by the maximum direction spectrum are more conservative in medium and short periods, and those selected by sum of mean square spectrum and geometric average spectrum are more conservative in medium and long periods. When using maximum direction spectrum for ground motion selection, the sensitivity of effective peak acceleration (EPA) and effective peak velocity (EPV) of the selection results are higher, while those of sum of mean square spectrum and geometric average spectrum are lower. In practical engineering application, it is suggested that different ground motion parameters should be selected according to different engineering requirements under the premise of ensuring economy and practicability.