To explore the best lubrication strategy for the service process of high-speed rolling bearing under the condition of oil-gas lubrication, the lubrication performance of H7003C series angular contact ball bearing made of steel and Si₃N₄ ceramic rolling element materials at different wear stages was experimentally studied. The lubrication characteristics of rolling bearing in the early, middle and critical failure stages were simulated by standard condition test, accelerated wear test and limit wear test. The test results show that there are an optimal working condition range for H7003C series bearings in the initial stage of wear. As the oil air lubrication supply pressure is 1 Bar with quantity of 0.8-0.98 ml/min, the bearing temperature changes less than ±3.5℃ and the vibration velocity variance of the bearing in stable operation is less than 0.029, the lubrication performance of the bearing is the best under this condition. When the vibration value increases to 2-2.5 time of the initial value of wear, the lubrication condition of the bearing can be improved by adjusting the oil supply interval reasonably. Therefore, under the condition of oil-gas lubrication, the bearing has different lubrication requirements in different wear stages. The oil-gas parameters can be reasonably adjusted according to the changes of working conditions in different wear stages, so as to obtain the best lubrication strategy of rolling bearing under various working conditions.