In order to accurately evaluate the bursting pressure of Cu-Ni alloy tube with groove defect, the prediction model of burst pressure was established and the bursting process was simulated, the correction function was determined by the least square method, and the hydrostatic blasting test was carried out. Both the numerical simulation and test results show that the error between DNV standard and numerical simulation results decreases first then increases with the increase of corrosion depth. The prediction formula established by the correction function containing defect depth parameter can effectively predict the burst pressure of the Cu-Ni alloy pipe, and the test proves that the formula has a high accuracy. Compared with the crack morphology of blasting test, the numerical simulation of pipe bursting process under the condition of only internal pressure is better. The ductile fracture occurs when the residual wall thickness is thin, while the brittle fracture occurs when thick. The study of burst pressure can provide theoretical basis for scientific maintenance of ship pipeline and has great significance to guide pipeline condition assessment.