To imitate the chameleon skin, a method using microfluidic color-changing system to camouflage films is proposed. By sensing and collecting environmental color change information, the control signal of the microfluidic system can be adjusted in real-time to drive the dyed liquids circulating in the micro channels of the camouflage film to achieve dynamic cloaking and camouflage. The microstructure of the film and the working principle of the microfluidic color-changing system are introduced. The mechanism to generate the color signal by deep learning image completion algorithm and image processing technology is illustrated. “Canny” double-threshold edge detection algorithm and color similarity are used to analyze and evaluate the camouflage. The tested results show that the camouflaged chameleon skin is not obvious and has a relatively high compatibility with environmental backgrounds and the dynamic cloaking effect can be achieved. The camouflage film implemented by the microfluidic color-changing system can be applied to various occasions such as camouflage uniforms for officers and soldiers, robot skins, weapon equipment, and camouflage nets for military facilities.