In recent years, the rapid changes in the water transportation industry have also led to the frequent occurrence of ship-bridge collisions. Although the bridge collision prevention facilities currently used can resist the impact of ships, there is still a lack of reproduction and quantitative analysis of the whole process of ship-bridge collisions. In order to map the relationship between impact force and impact depth of ship bow under large deformation and reproduce the collision process of ship bridge. Firstly, a large mass horizontal impact test device is used to carry out several successive cumulative collision tests on the reduced size bow model of 500 DWT without bulbous bow. Secondly, LS-DYNA, a large finite element analysis software, was used to build a refined reduced bow model, and the simulation analysis of multiple consecutive cumulative collisions was carried out by restart function, and compared with the test results. Test and simulation results show that with the accumulation of the number of impacts, the peak single impact force and the accumulated impact deformation of the reduced-scale ship bow model are gradually increased, while the increment of each impact deformation and the impact time are gradually decreased. There is a basic correspondence between the deformation of collision damage to the ship bow structure and the absorbed energy.