Reinforced concrete slabs during the service period may suffer repeated impacts from falling objects with different impact angle. The capability of reinforced concrete slabs to resist multiple impacts, the performance evolution of reinforced concrete slabs under multiple impacts and the residual performance evaluation are vital to people's livelihood and safety. Notably, the multiple impact loading system is the key to investigate the impact resistance of reinforced concrete slabs. To study the impact resistance of reinforced concrete slabs under multiple impacts, drop hammer and pendulum impact test was carried out, and the impact performance of reinforced concrete (RC) slabs under amplitude impacts was scrutinized with the cumulative damage characteristics of the RC slabs analyzed, the impact force-time history curves of each impact and the global and the local deformations of the RC slabs after each impact examined. The energy-absorbed capacity and the residual performance of the impacted slab were explored. The experimental results show that the deformation of the RC slabs is affected by the impact angle with the oblique impact producing a greater influence on the safety performance of reinforced concrete slabs. Moreover, the energy-absorbed capacity of the RC slabs is reduced due to the amplitude impact force which causes more damage of the slab. The impact response of the slab under amplitude impacts proves to be more stable than that of the repeated-impact with a constant weight.