In response to issues of low efficiency, single purification capacity and potential secondary pollution associated with existing manned spacecraft air filtration and purification technology, an integrated technology route of man-machine coexistence based on YMn₂O₅ mullite catalyst synergized with ozone catalytic oxidation was proposed. The YMn₂O₅ catalyst prepared by citric acid gel-sol method was characterized by X-ray powder diffractometer and scanning electron microscope. The results revealed that the catalyst′s surface possesses abundant active sites, which are conducive to the production of a large number of reductive substances under the synergistic effect of ozone. This technology route enables efficient, green and low-energy consumption degradation and elimination of volatile organic compounds, viruses, bacteria and other microorganisms in the air through the highly active O* produced during the reaction process. Based on this technology route, a prototype equipment integrating air purification and virus elimination (Mcaton) was designed and produced by combining 3D modeling and 3D printing technologies. For different volatile organic pollutants and virus aerosols in the air, the purification and elimination effects of the prototype on gas pollutants and virus aerosols were tested in a sealed chamber, which validated the ability of the Mcaton technology to achieve rapid and efficient purification of various volatile organic pollutants and elimination of viruses and bacteria.