A fault tolerant control scheme based on integral sliding mode surface is developed for spacecraft attitude stabilization in the presence of actuator faults, misalignments, magnitude saturation and external disturbances simultaneously. This approach is based on a novel integral-type sliding mode control strategy to compensate for these un-desired issues without controller reconfiguration. Especially, it guarantees the reachability of the system states by involving adaptive control technique to relax the boundary information in advance. A sufficient condition for the controller to accommodate magnitude saturation is also presented and then the fault tolerant attitude control system can be guaranteed theoretically to be asymptotically stable by using Lyapunov method. Numerical simulation results shows that the proposed control law can quarantee the stability of the spacecraft attitude control system in the presence of actuators' failures, and it has good robust performance.