| 引用本文: | 杜智,姚军燕,李玉洁,李武丹.聚乳酸/杆菌肽静电纺丝纤维的体外释药研究[J].材料科学与工艺,2015,23(5):52-58.DOI:10.11951/j.issn.1005-0299.20150510. |
| DU Zhi,YAO Junyan,LI Yujie,LI Wudan.Drug controlling release behavior of electrospun Poly(lactic acid)/Bacitracin drug delivery system[J].Materials Science and Technology,2015,23(5):52-58.DOI:10.11951/j.issn.1005-0299.20150510. |
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| 摘要: |
| 为探讨聚乳酸纤维结构形貌对杆菌肽药物的缓慢释放行为及作用机理,通过静电纺丝法制备了聚乳酸/杆菌肽单轴纤维、聚乳酸/杆菌肽串珠和(聚乳酸/杆菌肽)-聚乳酸同轴核-壳纤维等聚乳酸/杆菌肽药物缓释体系,并采用红外光谱法和差热分析法对其化学结构和热性能进行了表征.利用紫外分光光度计法研究了不同载药体系的体外药物释放行为,并探索了不同降解时期载药纤维的质量和形貌变化规律.研究表明:杆菌肽与聚乳酸主要为物理结合；聚乳酸单轴纤维和串珠对杆菌肽的扩散释放机理,属于纯Fick扩散；采用单轴和同轴静电纺丝技术可以获得两种不同释药特性的载药纤维.单轴纤维和串珠能够将药物快速释放,适合抗生素的治疗；同轴纤维中药物受控释放,更适合长期、小剂量的药物释放. |
| 关键词: 静电纺丝 聚乳酸 杆菌肽 药物释放 降解 |
| DOI：10.11951/j.issn.1005-0299.20150510 |
| 分类号:TQ340.64 |
| 基金项目:西北工业大学2014届本科生毕业设计(论文)重点扶持项目(GEKY9003)；西北工业大学基础研究基金资助项目(JCY20130148). |
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| Drug controlling release behavior of electrospun Poly(lactic acid)/Bacitracin drug delivery system |
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DU Zhi, YAO Junyan, LI Yujie , LI Wudan
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(Department of Applied Chemistry, Northwestern Polytechnical University, Xi′an 710072, China)
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| Abstract: |
| Poly(lactic acid)/Bacitracin (PLA/BAC) drug delivery system (DDS) of uniaxial fibers, beads and (PLA/BAC)-PLA coaxial fibers were prepared by electrospinning for the study of the effect of the structure and morphology of electrospun PLLA fiber on the release behavior to the drug of bacitracin as well as the release mechanism. The chemical structures and thermal properties of electrospun PLA/BAC DDS were analyzed by Infrared Spectroscopy and Differential Scanning Colorimetry. UV Spectrophotometer was used to characterize the drug release behaviors in vitro. The changes of the structure in the different degradation period were explored by evaluating the variation of quality and morphology. The results showed that the prior bond between BAC and PLA was physical. The diffusion and release mechanism of BAC in DDS fibers and beads were confirmed to be Fick diffusion. Uniaxial and coaxial electrospinning could achieve two different drug release behaviors. The drug release speeds of uniaxial fibers and beads of PLA DDS were rapid and suitable for the antibiotic treatment; coaxial fibers had drug controlling release speed and were suitable for the long-term and low-dose drug treatment. |
| Key words: electrospinning Poly(lactic acid) Bacitracin drug release degradation |
