| 引用本文: | 张润峰,徐欣东,王清,陈山.多糖涂覆的氧化铁纳米粒子的合成及其药物递送应用研究进展[J].材料科学与工艺,2021,29(5):9-22.DOI:10.11951/j.issn.1005-0299.20210061. |
| ZHANG Runfeng,XU Xindong,WANG Qing,CHEN Shan.Research progress on synthesis of polysaccharide-coated iron oxide nanoparticles and their drug delivery applications[J].Materials Science and Technology,2021,29(5):9-22.DOI:10.11951/j.issn.1005-0299.20210061. |
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| 摘要: |
| 近年来,氧化铁纳米粒子(Iron Oxide Nanoparticles,IONPs)由于具有超顺磁性、生物相容性、比表面积大、易分离等特点而备受科学界关注。然而,裸露的IONPs容易聚集和氧化而失去其应有的特性,采用多糖进行涂覆不仅能提高IONPs的稳定性和生物相容性,还能通过多糖与其他生物活性物质结合,赋予INOPs新的功能。多糖涂覆的IONPs充分结合了多糖的生化特性与磁芯的理化特性,在药物递送中展现出巨大的应用潜力。本文综述了多糖涂覆IONPs的合成方法、合成过程的影响因素、多糖与IONPs的结合机理及其在药物递送中的应用,最后对多糖涂覆的IONPs的合成及其在药物递送方面的应用进行了总结和展望。 |
| 关键词: 多糖 氧化铁 纳米粒子 合成 药物递送 |
| DOI：10.11951/j.issn.1005-0299.20210061 |
| 分类号:TB333 |
| 文献标识码:A |
| 基金项目:国家自然科学基金地区科学基金资助项目(21768001). |
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| Research progress on synthesis of polysaccharide-coated iron oxide nanoparticles and their drug delivery applications |
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ZHANG Runfeng, XU Xindong, WANG Qing, CHEN Shan
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(College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China)
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| Abstract: |
| In recent years, iron oxide nanoparticles (IONPs) have attracted much attentiondue to their unique properties, such as superparamagnetism, biocompatible, great specific surface area, and ease of separation. However,bare IONPs tend to lose their natural properties because of aggregation and oxidation. Polysaccharide coating not only improves the stability and biocompatible of IONPs, but also confers new functions on INOPs by combining with other bioactive substances.Polysaccharide-coated IONPs fully combine the biochemical properties of polysaccharides and the physical and chemical properties of magnetic cores, revealing great potential for drug delivery. This paper reviews the synthesis methods of polysaccharide-coated IONPs, the influencing factors of the synthesis process, the binding mechanism of polysaccharides and IONPs and its application in drug delivery.Finally, the synthesis of polysaccharide-coated IONPs and their application in drug delivery are summarized and prospected. |
| Key words: polysaccharide iron oxide nanoparticles synthesis drug delivery |
